Family Alignment Documentation

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Revision as of 14:30, 12 December 2006 by Bosborne11@verizon.net (talk) (Analysis of Silent Substitutions Within a Genome or Across Multiple Genomes)
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Introduction

These pages describe approaches to characterizing sequence families in some set of related organisms. There are many ways to do this so our examples, though robust and proven by practice, are selected from a multitude of possible examples. The focus is on approaches that use a Bio* toolkit ([BioJava, BioPerl, BioPython, BioRuby) since these packages offer the user different workflow possibilities but home-grown solutions are also discussed.

All of our examples are descriptions of bioinformatic workflows or pipelines. A workflow is comprised of a set of analytical applications, performing the analyses themselves, and some set of scripts that hand data to applications and take results from these same applications. One will also frequently encounter some set of critical filters (e.g. in English, "only write those sequences to a file that match the query sequence with a p < .0001" or "get all nucleotide sequences > 250 bp in length from the input file"), and these filtering steps may be performed by an application or by a script.

Analysis of Gene & Protein Families from Fungal Genomes

Based on the work of Jason Stajich (http://fungal.genome.duke.edu/).

Applications

Databases


Analysis of Silent Substitutions Within a Genome or Across Multiple Genomes

Based on the work of Amy Bouck (http://visionlab.bio.unc.edu/).

Applications

Databases

Reconciling the Multiple Trees Created by Analyzing Genomes

Based on the work of Stefanie Hartmann (http://visionlab.bio.unc.edu/).

Applications

Databases

  • www.phytome.org
    • Alignments and phylogenies for ~27,000 gene familes derived from 140 plant species